5-year-old rats, the

Ate(3/16 and 2/16 for male and female); and for 1.5-year-old rats, the 70 mmHg target resuscitation pressure group had the best survival time (8.6 ?4.8 hours and 7.7 ?4.1 hours for male and female) and 24-hour survival rate(2/16 and 1/16 for male and female). The survival time and 24-hour survival rate of 6-week-old rats was higher than for 14-weekold rats and 1.5-year-old rats (Figure 3).Hemodynamics, blood gases, tissue blood flow, and vital organ function HemodynamicsThe baseline hemodynamic parameters of MAP, LVSP and ?dp/dtmax had an increased trend with increasing age but no statistical significance. MAPs were 104.6 mmHgFigure 2 Effects of resuscitation pressure on blood loss and fluid requirement in hemorrhagic shock. (A), (B), (C): Amount of blood loss during phase I and phase II. (D), (E), PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/12027669 (F): Fluid requirements to maintain the target resuscitation pressure during phase II. Data presented as mean ?standard deviation (n = 16/group). Analysis of variance showed there were significant differences in blood losses and fluid requirements between ages and different target resuscitation pressures (P < 0.01), but no significant differences between sexes (P > 0.05). *P < 0.05 versus no treatment group (No); #P < 0.05, ##P < 0.01 versus 40 mmHg group (post-hoc Tukey test).Li et al. Critical Care 2013, 17:R194 http://ccforum.com/content/17/5/RPage 5 ofFigure 3 Effects of different target resuscitation pressures on animal survival in hemorrhagic shock. (A), (B), (C): Survival for 6-week-old rats. (D), (E), (F): Survival for 14-week-old rats.(G), (H), (I): Survival for 1.5-year old rats. Data presented as mean ?standard deviation (n = 16/ group). Analysis of variance showed there were significant differences in animal survival time between ages and different target resuscitation pressures (P < 0.01), but no significant difference between sexes (P > 0.05).(6 weeks) and 126.2 mmHg (1.5 years), LVSPs were 131.3 mmHg (6 weeks) and 146.21 mmHg (1.5years), and +dp/ dtmax values were 5,529.8 mmHg/second (6 weeks) and 6,308.2 mmHg/second (1.5 years). These parameters were significantly decreased after hemorrhage at the end of phase I (uncontrolled hemorrhagic shock) in all age groups. During the permissive hypotension resuscitation period (phase II) and the definitive resuscitation period (phase III), all MAP values could be maintained at the set MAP level (40, 50, 60, 70 and 80 mmHg during phase II, and 80 mmHg during phase III). During the observation period (phase IV), these hemodynamic parameters demonstrated significant differences between ages and different target resuscitation pressures (P < 0.01), but Phenyl (4-chloro-3-fluorophenyl)carbamate no significant difference between sexes (P > 0.05). The 50-mmHg target resuscitation pressure group in 6-week-old rats and 14week-old rats had the best MAP, LVSP and dp/dtmax atthe end of phase IV, whereas in 1.5-year-old rats the 70-mmHg target resuscitation pressure group had the best MAP, 4]oxazin-3(4H)-one 4-Bromo-5-chloro-2-nitroaniline (S)-3-Amino-3-phenylpropan-1-ol 2-Amino-5-(trifluoromethyl)benzoic acid 3-Bromo-2-methylbenzaldehyde (Z)-4 LVSP and dp/dtmax at the end PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22993420 of phase IV. Since -dp/dtmax data paralleled the +dp/dtmax data, the data are not shown here (Tables 1, 2 and 3).Blood gasesThe normal values of blood pH, PaO2 and partial pressure of carbon dioxide 3-Amino-1H-indazole-4-carbonitrile showed no differences in the different age and sex groups. The blood pH in all groups of rats showed the same extent of decrease during phase II as compared with phase I. During phases III and IV, blood pH had some extent of recovery in all resuscitation pressure groups in all ages of rats. Blood pH in rats at 6 weeks and 14 weeks o.